Yintoni i-anandamide?
Yimichiza edla ngokubizwa ngegama elithi "molecule yolonwabo" kuba igama layo, uananda, livela Kwisisanskrit, kwaye lithetha ulonwabo okanye ulonwabo. Igama layo elipheleleyo lekhemikhali Yi-n-arachidonoylethanolamine. Yeyeqela lezinto ezikumzimba obizwa ngokuba yi-fatty acid amides, eziyinxalenye yenkqubo ye-endogenous yomzimba (endo, ethetha" ngaphakathi") inkqubo ye-cannabinoid. Oku kuchasene ne cannabinoids zangaphandle
(println "outsourcing") ezifana THC, CBD njl oku kudliwe.
Enyanisweni, isakhiwo seekhemikhali se-anandamide sifana kakhulu ne-THC. Omnye unokuphantse athi babengabazala, nge-THC njenge - cannabinoid yangaphandle yangaphandle kunye ne-anandamide njenge - "endogenous"yangaphakathienye.
I-Anandamide inxibelelana nee-receptors ZE-CB2 kunye NE-CB1; oku kuthetha ukuba kubangela into ebuchotsheni kunye nenkqubo ye-nervous central. Njenge-THC, yi-cannabinoid ebangela imvakalelo eyahlukileyo "ephezulu", kunye nokwandisa ukutya kunye nokozela kunye nokuphumla. Ikwadlala indima ebalulekileyo kweminye imisebenzi ebalulekileyo emzimbeni womntu.
Cannabinoids kunye nengqondo
Kwakungoo-1960 Apho Uraphael Mechoulam, isazinzulu kunye nezityalo ezivela Kwasirayeli, waqala ukubekwa bucala i-cannabinoids. Ekuqaleni ukumisela ubume beekhemikhali BE-CBD, yena kunye neqela lakhe lophando bakwazile ukwahlula I-THC njengeyona nto iphambili ye-psychoactive efumaneka kwi-cannabis.
Oku, kunjalo, kukhokelelaizifundo ngeziphumo ZE-THC engqondweni nasemzimbeni kwaye ekugqibeleni sisizathu sokuba isayensi iyazi ngoku ngenkqubo ye-endocannabinoid. Emva komsebenzi obalulekileyo Kamechoulam kwicandelo le-endocannabinoids, izazinzulu zagqiba kwelokuba into efana ne-cannabinoid receptor inokufumaneka kwindawo ethile kwingqondo okanye emzimbeni ngokwawo. Oku kwakhokelela kwisazinzulu Uallyn Howlett, kunye neqela lakhe Kwiyunivesithi Yasest. Louis, bafumana ubungqina obucacileyo bokuba umzimba womntu uqulethe ii-cannabinoid receptors zawo, kwaye I-THC ingena ngqo kwezi receptors. Oku kufunyenwe kwabangela umbuzo wokuba kutheni umzimba unokuba ne-cannabinoid receptor (engena PHANTSE ngaphakathi KUYO) ukuba I-THC ayenzeki ngokwendalo emzimbeni ngokwawo. Lo ngumbuzo ojamelene nawo oososayensi kwaye yintoniekugqibeleni, wafumanisa i-anandamide.
Ukuba umzimba uvelise i-cannabinoid yayo yendalo yafunyanwa liqela Likaraphael Mechoulam ngelixa beqhuba uphando lwabo lokuqala. Nangona kunjalo, bekungekho ngo-1992 ukuba iqela lophando lokuqala-Uwilliam Devane Nolumir Hanus-bafumana isiqwenga sokugqibela sephazili, abayibiza ngokuba nguanandamide (iphefumlelwe, njengoko kukhankanywe ngaphambili, ngegama Lesisanskrit elithi bliss: "Ananda"). Ngelixa I-THC ingena phantse kwi-cannabinoid receptor yomzimba, i-anandamide ingena ngokugqibeleleyo kuyo.
Ukufunyanwa kwe-anandamide kube negalelo elikhulu ekuqondeni kwesayensi malunga ne-cannabis kunye nomzimba womntu. Ukuhlukanisa nokufumanisa i-endocannabinoiduqinisekisile ukuba kukho inkqubo epheleleyo ye-endocannabinoid emzimbeni. Ii-cannabinoid receptors kunye ne-cannabinoids eveliswe ngokwendalo zibonisa ukuba kukho inkqubo epheleleyo ye-cannabinoids, ngaphandle kwesidingo se-cannabis, esebenza ngaphakathi kwengqondo nomzimba womntu.
Wenza ntoni uanandamide?
Kusekho okuninzi ukufumanisa malunga nendlela i-anandamide esebenza ngayo emzimbeni. Ngapha koko, iyinxalenye yeenkqubo ezintsonkothileyo ngaphakathi kwethu. Inokubangela imeko enamandla ngakumbi yolonwabo kunabasebenzisi abaninzi be-cannabis baya kuyifumana emva kokutshaya okanye ukuyifaka. Ukongeza, i-anandamide ikwasebenza kwezo ndawo zobuchopho ezichaphazela iimvakalelo zentlungu, inkumbulo, ukutya, ukuhamba kunye nezinto ezinjeinkuthazo.
Ikwachaphazela inkqubo yokuzala kwaye, ngenxa yoko, ukuzala. Njengoko i-neurotransmitter, iphulwa ngokukhawuleza ngaphakathi komzimba, yingakho umphumo wokuphakamisa awuhlali ixesha elide. I-Anandamide inyusa i-neurogenesis-ukwakheka kwee-neurons ezintsha, okanye unxibelelwano olutsha lwe-neural. Ngenxa yolu phawu lukhethekileyo, izazinzulu zithi i-anandamide inokusebenza ngokuchasene noxinzelelo kunye noxinzelelo. Okubangel 'umdla kukuba, ikwadluliselwa kwiintsana ezisandul' ukuzalwa ngobisi lwebele lukamama.
I-Anandamide, I-THC KUNYE NE-CBD - Indlela Esebenza ngayo
Xa i-cannabis ifakwe, i-thc compound compound ilinganisa oko i-anandamide iya kuyenza. Umahluko kukuba I-THC ihlala emzimbeni ixesha elide kune-anandamide eyenza, njengoko kuchaziwe apha ngasentla, iyaphukangokukhawuleza okukhulu.
Kulabo bavelisa i-anandamide encinci, ukongezwa KWE-THC kunye nokukhuthaza i-receptor ye-cannabinoid kunokudala isiphumo esamkelekileyo.
Ngokuchasene noko, I-cbd inxibelelana nomzimba womntu ngendlela eyahlukileyo, engenasiphumo sengqondo; endaweni yoko, inefuthe elikhuthazayo ekusebenzeni kwendalo kwenkqubo ye-endocannabinoid.
Ithintela ukuveliswa KWE-FAAH, eyi-enzyme emzimbeni eyaphula i-anandamide. Oku kuthetha ukuba i-anandamide ihlala ixesha elide xa I-CBD ingena emzimbeni. Ikwakhuthaza umzimba ukuba uvelise ngaphezulu. Oku kudala imvakalelo yokwanda kwempilo kunye nolonwabo, kunye nokunciphisa ukuvuvukala kunye nentlungu.
Ezinye izazinzulu zinayokucetyiswa ukuba i-anandamide iveliswa ngokwendalo emzimbeni xa umntu ekwimeko yokuphumla okunzulu okanye uxinzelelo oluphuculweyo: umzekelo, xa usenza okanye umamele umculo, umdaniso, ukubhala okuyilayo, njl. ngokusisiseko, nawuphi na umzamo owandisa ugxininiso okanye wokuphumla. Ke, le endocannabinoid iyimfihlakalo inokudlala indima yokuba kutheni i-cannabis inandipheka kwindalo iphela kwabaninzi, nokuba badala kangakanani, isini, okanye imvelaphi.
I-Psychedelics kwi-20th century-ixesha lokukhula
Imbali Ye-Microdosing
