Ukufunyaniswa kwezinto zakudala ezivela kumzantsi we-US, eMexico nasePeru kubonisa ukuba i-mescaline-equkethe i-cacti yayisetyenziswe kwimikhosi yamawaka eminyaka. ISan Pedro cactus igqame kwimixholo yeMescaline. Ukusetyenziswa kweSan Pedro cactus (okanye ngegama layo lendawo, iWachuma) eyayixhaphakile ePeru nangaphambi koBukhosi be-Inca, yancitshiswa kakhulu emva koloyiso lwaseSpain, kodwa phakathi kwinkulungwane yama-20 yasasazeka ngokuthe ngcembe ukusuka ePeru ukuya eBolivia kwaye. Chile, ikakhulu njengeyeza.
Ukuchongwa kwe-mescaline njengento esebenzayo kwiSan Pedro cactus kwafunyanwa kuphela ngo-1960. Le nto ifumaneka kakhulu phantsi kwexolo. Igama elithi San-Pedro, elanikwa icactus emva koloyiso lwaseSpain, libhekisa kwiSt. Peter, lowo ngokwenkolelo yobuKristu ephethe izitshixo zamasango ezulu. Okwangoku, isasetyenziselwa iinjongo ezifanayo yiCawa yaseMelika yaseMelika, eyasekwa ekupheleni kwenkulungwane ye-19.
