IPeyote inesantya esicothayo sokukhula kunecacti eninzi, idinga iminyaka emininzi (amashumi eminyaka) ukuze ifikelele ekuvuthweni nasekudubuleni. Iisampuli zasekhaya zinokutyatyamba emva kweminyaka emi-5-7.
Ukwembiwa kwezinto zakudala kumazantsi e-US, eMexico nasePeru kubonise ukusetyenziswa komkhosi we-cacti ene-mescaline iminyaka engaphezu kwe-6000. I-Mescaline yinto eqhelekileyo eyenzekayo kwiintlobo ezahlukeneyo ze-cacti, kunye ne-Peyote ebonisa umxholo ophezulu. Ukusetyenziswa kwe-peyote kwakuxhaphake kulo lonke uBukumkani base-Aztec nakumantla eMexico kwaze kwaba yilapho iSpeyin ithatha, eyayinciphisa ukusetyenziswa kwayo kwimibhiyozo ngenxa yezizathu zonqulo. Ngasekupheleni kwenkulungwane ye-19, ukusetyenziswa kwepeyote kwasasazeka phakathi kwamaMerika Omthonyama ukuya emantla.
Uninzi lwe-mescaline kwi-peyote ifumaneka phezulu kwesityalo esibizwa ngokuba yi "iqhosha", elidliwayo elomileyo okanye kwi-infusion. I-Peyote ibonakaliswe ukuba inceda ekusombululeni iingxaki, ukuphucula ubuchule kunye nengqondo, kunye nokuphucula ukufunda. Yayisetyenziswa ngokwemveli njengesityalo sonyango ukunyanga izigulo ezahlukeneyo, ezifana neentlungu, amanxeba, iimeko zolusu kunye nokulunywa yinyoka.
