Ngelixa i-cannabis yezonyango ingelilo iyeza layo, inokunyanga ngokufanelekileyo ezinye zeempawu ezingathandekiyo ezinje ngokudumba, yenye yezona zinto zibangela iintlungu kunye nokungonwabi okunxulunyaniswa nale meko. Kwizigulana ezininzi ezinesifo Sikacrohn, ukufuna unyango olufanelekileyo kunokuthatha iminyaka. Kunokuba nzima ngakumbi kwaye kungathandeki kulowo ugulayo, ngokwasemzimbeni nangokwasengqondweni, ubuncinci ngenxa yefuthe elibi elinokuba nalo kumandla omntu okufumana ubomi obuqhelekileyo. Kwiimeko ezininzi, ezi mpawu zilawulwa ngamayeza kagqirha, akukho nanye kuwo ebonelela ngesiqabu sexesha elide.
I cannabis yezokwelapha inika izigulane ezithile zesifo Se Crohn enye indlela yokulawula iimpawu zazo ngaphandle kokuxhomekeka kuphelaunyango oluqhelekileyo, oluhlala lubangela iziphumo ezininzi ezingathandekiyo.
Yintoni Isifo Sikacrohn?
Inzululwazi yezonyango isazi kancinci ngesifo Sikacrohn kunye nezizathu zaso. Sisifo esihlasela amathumbu kunye nomgudu wesisu, obangela ukuvuvukala okukhulu. Oku kuthetha ukuba kunokuchaphazela amathumbu omntu, isisu kunye nomqala. Uninzi lwabantu abanesifo Sikacrohn bafumana intlungu kwikholoni okanye inxalenye yokugqibela yamathumbu amancinci. Ifaniswa nesifo samathumbu esicaphukisayo. Kuze kube ngoku, izazinzulu ziye zakwazi ukucacisa ukuba kutheni abantu bafumana isifo Sikacrohn.
Abanye bakholelwa ukuba i-genetic disorder ichaphazela ukusebenza ngokuqhelekileyo kwenkqubo yomzimba yokuzikhusela. Abanye bakholelwaoku kuthetha ukuba kukho ukungalingani kwi-gut flora. Le ngcamango ingachaza ukuba kutheni i-cannabis iphumelele kakhulu ekunyangeni iimpawu zayo. Ngokubanzi, izigulana ezinesifo Sikacrohn zihlala zineenkantsi zesisu kunye nesisu esikhathazekileyo, isifo sohudo esibi nesingapheliyo, ukopha okungapheliyo, kunye nokungakwazi ukugcina ubunzima.
Isifo sikacrohn senza kube nzima kakhulu ukuba umzimba ufumane izondlo ozifumanayo. Oku, ngokukhawuleza, kuya kubangela ukusilela kwesondlo okwenza kube nzima ngakumbi ukuba umzimba uphinde uchache. Inokubangela imvakalelo engathandekiyo yokulahleka. Uninzi lwezigulane ezinesifo Sikacrohn ziphuhlisa eso sifo kamva ebomini, kwaye ngokuqhelekileyo kwenzeka ngokungalindelekanga. Ufuna unyango olukhawulezileyo kwaye ezinyeutshintsho kwindlela yokuphila olunokuba nzima ukuyilandela.
I-THC kunye nokunciphisa ukuvuvukala
I-Cannabis ibonakaliswe ukuba iyasebenza kakhulu kubantu abanesifo Sikacrohn ngenxa yokukwazi kwesityalo ukunciphisa amanqanaba okuvuvukala. Oku kuye kwaboniswa ngokuphindaphindiweyo ngophando lokuphononongwa koontanga, kubonisa ukuba I-THC inako ukunciphisa ukuphendula okuvuthayo okwenzeka emzimbeni. Ukudumba, mhlawumbi, lolona phawu luphambili lwesifo Sikacrohn kwaye lolona kunzima ukululawula.
Oogqirha badla ngokucebisa abaguli ukuba benze iinguqu ezibalulekileyo ekutyeni, kuquka nokuphepha ukutya okubangela ukudumba, njengeshukela, amafutha, ukutya okucutshungulwa kakhulu. Abanye oogqirha bancomela i-opioids njengonyango lwezinye iimpawu. Nangona kunjalo, kukho ukulahlekainkxalabo esemthethweni yokuba unyango lwe-opioid aluyonyusa kuphela umngcipheko wosulelo lwamathumbu, kodwa luyakhobokisa kakhulu, ke ngoko aluyondlela efanelekileyo yonyango lwexesha elide, kwaye ayidlala indima ekunciphiseni ukudumba.
Ukusebenzisana kwe-cannabis kunye nenkqubo ye-endocannabinoid yabantu kukhuthaza impendulo yokulwa nokudumba. Oku kuchaza ukuba kutheni i-cannabis isetyenziswa kunye nezigulana ezinesifo se-multiple sclerosis kunye nesifo samathambo kunye nezinye iimeko ezininzi. Kwabaninzi, ukunciphisa ukuvuvukala kuyisiqalo kunye nesinyathelo sokuqala kwinkqubo yokuphilisa.
I-Cannabinoids njenge-THC inokunyusa izinga lokuphilisa apho kwenzeka khona oku. Kwizigulane, oku kubhekisela ngokukodwa kumanxeba abangelwa yikholoni.
CBD ukukhuselaindlela yesisu
Kukho ubungqina obubonisa UKUBA I-CBD ikhusela i-gastrointestinal tract. Xa umzimba ufumana impendulo yokuvuvukala, uvelisa into ebizwa ngokuba yi-interleukin-17,eyinto yokuvuvukala. Le nto yonakalisa i-membrane ye-mucous ngaphakathi kwendlela yesisu, ekhokelela kwiingxaki ezingakumbi kubantu abanesifo Sikacrohn. I-CBD isebenza ukunciphisa umonakalo kwiimbumba ezinambuzane ngaphakathi KWIPHECANA LE-GI. Kukho ii-cannabinoid receptors kuwo wonke umzimba, kubandakanya nesisu, oko kuthetha ukuba xa inkqubo ye-endocannabinoid isebenza, le yenye yeendawo zokuqala ekujoliswe kuzo.
Isisu kunye ne-oesophagus ikakhulu zizaliswe zii-cannabinoid receptors, kwaye ezi receptors zifumaneka ikakhulu ngaphakathi.iiseli zamajoni omzimba kule nxalenye yomzimba.
Njengoko besesitshilo ngaphambili, kukho izikolo ezibini eziphambili zokucinga malunga nokuba yintoni ebangela isifo Sikacrohn: amajoni omzimba abuthathaka kunye nokungalingani kwiibhaktheriya zesisu. Mhlawumbi unokuchaza isizathu sokuba umntu ahlakulele isifo Sikacrohn. Inkqubo ye-endocannabinoid yomzimba inokujolisa kuzo zombini ezi zinto zinokwenzeka. Ukuba iiseli zamajoni omzimba ze-gi zibangelwa yinkqubo ye-endocannabinoid esebenza (yi-cannabis kule meko), umguli unokufumana isiqabu kwiimpawu.
Xa inkqubo ye-endocannabinoid isebenza ngokufanelekileyo, emva koko iintyatyambo zamathumbu zilawulwa yiyo. Ngoko ke, kunokutshiwo ukuba i-cannabis inokukwazi ukunyanga isifo Sikacrohn ngeendlela ezahlukeneyo.
Iklinikiizifundo
Izifundo zeklinikhi zibiza kakhulu kwaye zichitha ixesha, kwaye zicenga i-pharma enkulu ukuba yenze iindleko zokuphanda into engaqondakaliyo, ehlala inyeliswa ebizwa ngokuba "sisiyobisi sokuzonwabisa" njenge-cannabis, ehlala ingathandwa kakhulu noluntu ngokubanzi kunye nabenzi bomthetho ngokufanayo, iyaqhubeka nokuba ngumlo ophakamileyo. Nangona kunjalo, ngo-2013, isifundo esilawulwayo senzeka nabantu abangama-21 abanesifo Sikacrohn. Bonke abathathi-nxaxheba babeneempawu ezimandundu kwaye babengasaphenduli kumayeza aqhelekileyo ababewanikwa.
Iqela lahlulwe laba zimbini, iqela lolawulo elamkela i-placebo, kunye nelinye elamkela i-cannabis. Iqela elifumana i-cannabis lanikwa i-115 mg YE-THC ngosuku kwisithuba seeveki ezisi-8. Ngexesha lokubhala, phakathi kwabo 11 aboiqela le-cannabis, isiqingatha sixolelwe ngokupheleleyo. I-10 kwezingu-11 zichaze ukuphucuka kweempawu zabo, kwaye i-3 ikwazi ukuyeka ngokupheleleyo unyango lwazo lwangoku lwe-steroid.
Enye yeengxaki kuphela kolu phando, yayikukuba I-THC yanikwa izigulana kwifom yokutshaya, ngelixa ngoku yamkelwe ngokubanzi ukuba ukutya okanye iioyile zezona ndlela zisebenzayo zokuhanjiswa kwemicimbi yesisu ( kwaye, ewe, ukutshaya akucebisi, nokuba ).
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