Uxinzelelo oluphezulu lwe-intraocular luxhalabisa ngokukodwa abo banesifo soxinzelelo lwe-ocular, kuba yenye yezinto eziphambili zomngcipheko wokuphuhliswa kwe-glaucoma. Uxinzelelo oluphakanyisiweyo ngaphakathi kweliso lubangelwa kukungalingani kwimveliso kunye nokuhambisa ulwelo kwiliso (eyaziwa ngokuba yi "aqueous humor").
Ziziphi iintlobo ze-glaucoma?
Kukho iintlobo ezimbini ze-glaucoma, nganye yazo ikhokelela kwiimpawu ezahlukeneyo:
Primary-engile evulekileyo glaucoma (eyona ixhaphakileyo):
Apha, umguli unokufumana ukwehla ngokuthe ngcembe kumbono we-peripheral, ngokuqhelekileyo emehlweni omabini (umzekelo, xa kugxilwe kwindawo ethile, ukulahleka kombono we-peripheral kubangela ukungakwazi ukubona " ecaleni)
Kwinqanaba layo eliphambili, umbono wetonela uzaphuhlisa.
I-engile emxinwa yeglaucoma:
Olu hlobo lwe-glaucoma luza neziphumo ebezingalindelekanga ezininzi, kubandakanya:
Iintlungu zamehlo
Ukucaphuka kunye nokuhlanza (kunye neentlungu ezinzima zamehlo)
Ukuphazamiseka kwesiquphe, ngokufuthi ekukhanyeni okuphantsi
Umbono omfiliba
Umbono werainbow ojikeleze ukukhanya
Ubomvu bamehlo
Ekubeni abantu abaninzi bengabonisi iimpawu ze-glaucoma kude kube yinto ebalulekileyo, kaninzi umonakalo ongenakulungiswa, kubalulekile ukuba uhlolwe rhoqo kunye ne-ophthalmologist.
Indima yonyango enokubakho kwi-cannabinoids
Kuphononongo olupapashwe Kwi-International Journal Of Pharmacology And Biopharmacology, abaphandi bafunde iqela labantu abali-16 abaneengile ezivulekileyo zeglaucoma. Isibhozo sabathathi-nxaxheba babene-cardiovascularuxinzelelo lwegazi (uxinzelelo lwegazi oluphezulu) iight no. Kwafunyaniswa ukuba xa abathathi-nxaxheba inhaled A 2.8% amandla THC, izinga lentliziyo yabo ekuqaleni landa (ukubuyekeza igazi elincitshisiweyo kunye noxinzelelo intraocular okubangelwa THC). Xa intliziyo iqala ukumpompa igazi ngokukhawuleza ukugcina ukuhamba kwegazi kwiindawo ezibalulekileyo, ngoko umphumo kukuba uxinzelelo lwegazi kwaye, ngokukodwa, uxinzelelo lwe-intraocular luyancipha. Iziphumo zazinamandla kwaye zahlala ixesha elide kwizigulana ezinoxinzelelo lwegazi oluphezulu, zihlala ixesha elide ukuya kwiiyure ezi-3 ukuya kwezi-4.
Emva kolu phononongo, abaphandi abafanayo, bancediswa ngabanye oogxa, bapapasha inqaku kwiphephancwadi I-Ophthalmology elahlalutya iziphumo zeziphumo zabo zangaphambili, kwaye bafumanisa ukuba ukuncitshiswa koxinzelelo lwegazi okubangele ukunciphauxinzelelo lwe-intraocular lwenzeka imizuzu engama-60 ukuya kwengama-90 emva kokuphefumla. Kwakhona kwaqatshelwa ukuba ngenxa yokwanda kwenhliziyo kuyimpembelelo yecala ye-cannabis inhalation - oku kunokunika imvakalelo ye-palpitations kunye nobunzima bokukhanya kwabanye-abantu abane-hypotension ekhoyo
(uxinzelelo lwegazi oluphantsi) lunokufumana iimvakalelo ezinjengesiyezi kwinqanaba eliphakamileyo kakhulu, okwenza kungakufanelekanga kubo, kwaye ke ukunciphisa ukunconywa kwe-cannabis kwizigulana ezinjalo.
Ukongeza, njengoko ukuncitshiswa koxinzelelo lwegazi olubangelwa kukusetyenziswa kwe-cannabis iyonke (UKUSETYENZISWA KWE-THC) kunokuba neziphumo ezibi ekuhambeni kwegazi kwimithambo-luvo ye-optic esele yonakele ( enokuthi iphinde yonakalise imithambo-luvo ekuhambeni kwexesha), ukusetyenziswa konyango ngqo lwe-cannabinoid olunjeamaconsi okanye izitshizi zifaneleke ngakumbi.
Izifundo zibonise ukuba i-0.1% YE-THC kwioyile yezimbiwa ekhanyayo enikezelwa ngokuthe ngqo kwiliso ( okt, ngokwesihloko) kwizifundo zabantu ezinoxinzelelo lwegazi kuncitshiswe uxinzelelo lwegazi kwithambo legazi, elinokuviwa kwangoko emva kokuba intliziyo ifumene / impontshiwe), ikwakhokelela ekunciphiseni okufunwayo kuxinzelelo lwe-intraocular. Ubuninzi befuthe lokusetyenziswa kwesihloko SE-THC kuxinzelelo lwe-intraocular kuzo zombini izifundo zezilwanyana nezabantu kubonisiwe ukuba zivela malunga neeyure ezi-6 emva kolawulo, kwaye zihlala ngaphezulu kweeyure eziyi-8-12.
Isifundo sezilwanyana esipapashwe Kwi-Graefe's Archive For Clinical And Experimental Ophthalmology ngo-2000 safumanisa UKUBA i-HU-211 (i-synthetic, non-psychoactive cannabinoid derivative)ukulawulwa kwiso elinye lemivundla kunokunciphisa uxinzelelo lwe-intraocular. Iziphumo zaqala ngaphakathi kweeyure ze-1.5 emva kolawulo kwaye zahlala ngaphezulu kweeyure ze-6. Ukongeza, uxinzelelo lwe-intraocular lancitshiswa emehlweni apho I-HU-211 ingazange ilawulwe, nangona isiphumo sasingaphantsi, kwaye yahlala kuphela iiyure ze-4 zizonke.
Ukulawula ezinye iimpawu
Iimpawu ze-glaucoma ezinokuthi zikhutshwe yi-cannabis-based compounds ziquka isicaphucaphu, intlungu yamehlo, intloko kunye nokuhlanza.
Njengabo bonke abantu kunye nezifo, akukho siqinisekiso okanye ubungakanani obunye. Ayizizo zonke izigulana ze-glaucoma ezifumana ukuncitshiswa kweentlungu okanye isicaphucaphu emva kokusebenzisa i-cannabis, kwaye unyango oluqhelekileyo olunconyelwa ziingcali zezempilo lusengonyango lokuqala olunconywayo. Kwiukongeza, ezi mpawu zikhankanywe apha ngasentla zibangelwa luxinzelelo olongezelelekileyo kwiliso, olunokukhokelela kumonakalo kwimithambo-luvo ye-optic. Ngoko ke, kubalulekile ukunciphisa uxinzelelo lwe-intraocular, kungekhona nje ukulawula okanye ukunciphisa iimpawu. Nangona kunjalo, ukuba iimpawu aziphucuki ngonyango oluqhelekileyo, okanye ukuba unyango lubangela iziphumo ebezingalindelekanga ekunzima ukuzinyamezela, izibonelelo ezinokubakho zokusebenzisa icannabis kunokuba lukhetho olufanelekileyo ukuxoxa nogqirha.
Isiphelo
Ukusetyenziswa kwe-cannabis okwethutyana kunciphisa uxinzelelo lwe-intraocular kodwa alunyangi i-glaucoma. Nangona ukusetyenziswa kwe-cannabis kubonisiwe ukunciphisa uxinzelelo lwe-intraocular kwaye ngokubanzi baneprofayili efanelekileyo yokhuseleko, ukusetyenziswa kwayo kuthintelwe yinto yokuba ihlala kuphela iiyure ezimbalwa kwaye emva kokoifuna ukusetshenziswa kwakhona, okubaluleke kakhulu kuba iziphumo ze-psychoactive zinokuchaphazela ukusebenza kwemisebenzi ethile kubomi bemihla ngemihla, ezinje ngoomatshini bokusebenza, kwaye zibangele iziphumo ezithile ezichaphazela intliziyo ekufuneka ithathelwe ingqalelo ngononophelo okanye iphetshwe kubantu abanesifo sentliziyo esele sikhona.
Inkqubela phambili ekusebenziseni i-cannabinoids njengonyango lwesihloko ihlala iguquka, kwaye ngenye imini inokukhokelela kunyango olutsha ukunceda ngokusisigxina ukunciphisa uxinzelelo lwe-intraocular kwizigulana ezinesifo se-glaucoma.