I-Multiple Sclerosis: Kutheni I-Cannabis Inokusebenza

Yintoni I-Multiple Sclerosis (MS)?

Abantu abaninzi abaphila nale ntsholongwane bajamelana nentlungu enganyamezelekiyo mihla le. Uhlaselo lomzimba wabo oluqhubekayo kwinkqubo yalo yemithambo - luvo luyinyani yenkohlakalo yesi sifo, kwaye kuthetha ukuba abo baxhwalekileyo banokuphulukana ngokuthe ngcembe ukukwazi ukuhamba nokulawula izihlunu kunye namalungu abo, kwaye bakhangele phambili ekonakaleni ngokusisigxina kwiindawo ezinje ngombono kunye neminye imisebenzi yomzimba.

Ngamafutshane, i-multiple sclerosis sisifo se-neurodegenerative autoimmune esichaphazela ingqondo,intambo yomgogodla kunye ne-optic nerve. Ngesizathu esithile, amajoni omzimba aqala ukucinga ngeeseli zawo zemithambo-luvo njengabangeneleli abayingozi. Ngenxa yoko, iiseli zomzimba ziqala ukuhlasela iiseli zayo zemithambo-luvo. Umonakalo obangelwe ziziphumoekwakheni nasekwakheni izicubu ze-scar, ezibangela ukuba iiseli ze-nerve zingakwazi ukusebenza ngokuqhelekileyo kwaye ngoko zingakwazi ukuthumela iimpawu ezisisiseko kuwo wonke umzimba.

Esi sifo sichaphazela izigidi zabantu emhlabeni jikelele kwaye akukho nonyango eyaziwayo okwangoku. Amayeza anamandla adla ngokufuneka ukunyanga ISIFO SEMS, yaye kuye kubonwe imiphumo ebangel ' imincili kunyango lweeseli zesiqu, kodwa ukhetho olufana nolwamva lubiza imali eninzi, yaye kwiindawo ezininzi zehlabathi, alufumaneki kumntu onesi sifo. Kumazwe afana Ne-United Kingdom, umzekelo, unyango olusekwe kwiziqu alukafumaneki Kwinkonzo Yezempilo Yesizwe, kwaye ukwenza oko ngasese kubiza kakhulu ukuba kungafikeleleki kwi-99% yabaguli. 

Ngoko ke, injongo yonyango ezininzi ayinyangeki, kodwaukwehliswa okulinganiselweyo kwezinga lokuqhubekeka kwesifo, ukunyanga iimpawu, kunye nokukhawulezisa ukuchacha kokubanjwa okuyingozi kunye nokudodobala.

I-Cannabis inokunciphisa iimpawu ZE-MS, kwabanye abantu, ngeendlela ezahlukeneyo

Impumelelo enkulu ye-cannabis kunyango lweempawu ZESIFO SEMS sesinye sezizathu zokuba olu nyango lufumene ukusemthethweni kwihlabathi liphela njengoncedo oluqinisekisiweyo lwezonyango. I-Multiple sclerosis yenye yezifo eziphathwa nge-cannabis yezokwelapha kumazwe amaninzi-ingaba iyeza lokunyanga okanye ngohlobo lweoli ye-cannabis.

Iziphumo zokukhusela ingqondo

Izigulane ezine-multiple sclerosis zijongene ne-villain enkulu: ukuvuvukala. Xa iiseli zamajoni omzimba zisebenza, ziyakhululwaukukhuthaza ukuvuvukala kweeprotheni ezibizwa ngokuba yi-cytokines. Ezi cytokines zibangela ukudumba okungalawulekiyo kwingqondo. Oku ekugqibeleni kukhokelela ekutshatyalalisweni kweeseli zemithambo-luvo eziya zisiba mandundu ngakumbi iimpawu.

Izithako ezisebenzayo kwi-cannabis, ezibizwa ngokuba yi-cannabinoids, ziyi-anti-inflammatory agents. Ukongeza, iikhompawundi ezinje NGE-thc ye-psychoactive kunye NE-cbd engasebenziyo ye-psychoactive zinciphisa umsebenzi we-immune system, ukunceda ukumisa uhlaselo lwayo olunobundlobongela kwinkqubo ye-nervous central.

Le propati yesityalo iyenza isebenze ekulweni nezinye iintlobo zezifo ezizimeleyo ezifana ne-lupus.

I-Cannabinoids yenye yezinto ezimbalwa eziphambili ezikhuthaza i-neurogenesis — ukudala iiseli ezintsha zobuchopho —kubantu abadala.

Iikhompawundi ze-Cannabis zikwazii-antioxidants ezinamandla, zibanika iipropathi ze-neuroprotective. Isityalo sithatha ukulwa noxinzelelo lwe-oxidative, ukukhusela iiseli kunye nezicubu kumonakalo WE-DNA. Iimpawu zayo ze-neurogenetic, i-antioxidant kunye ne-anti-inflammatory properties zinganceda ukubonelela ngoncedo lonyango.

Ulawulo lweentlungu

Abantu abaninzi bayaqhubeka nokungqina ukuba bafumana iipropathi zokuthomalalisa iintlungu ezingapheliyo. Njenge-analgesic eqinisekisiweyo, ii-cannabinoids ezinje NGE-THC kunye NE-CBD zinxibelelana nee-receptors zeentlungu zomzimba. Ukukwazi kwesityalo ukunceda ukunciphisa ukuvuvukala kudlala indima kule nto, njengoko ukuvuvukala kunye nentlungu ihamba ngesandla.

Njengoko izicubu zomzimba ziqala ukudumba kwaye zicaphuke,ziqala ukuhla. Ukuqhekeka kwezi zicubu kubangela intlungu. Ukongeza, iiseli zemithambo-luvo zingathumela imiqondiso yeentlungu kuwo wonke umzimba njengoko zitshatyalaliswa.

Iziphumo zokuthomalalisa iintlungu ze-cannabis zavavanywa liqela Kwiyunivesithi Yasecalifornia, Esan Diego. Abaphandi baqhuba uvavanyo lweeklinikhi ukuvavanya imiphumo yokutshaya i-cannabis kwiintlungu zomzimba. Kwafunyaniswa ukuba i-cannabis, xa itshaywa, yayisebenza ngakumbi kune-placebo ekunciphiseni iimpawu kunye nentlungu kwizigulana ezinenkantsi enganyangekiyo kunyango okanye ukonakala kwemisipha.

Uncedo ekunciphiseni ukuqina kwemisipha kunye neenkantsi

Kwiyunivesithi Yasetel Aviv Kwasirayeli, uphando lubonise UKUBA i-CBD inokuba incede iimpuku ezikhubazekileyo ukuba ziphinde zifumane amandla azo okuhamba. Ezo rodentsukunyangwa NGE-CBD kubonakalise umonakalo omncinci kakhulu kwiiseli zabo zemithambo-luvo kunye nokudumba okuncinci ngokubanzi kunabo babengengabo. Iziphumo ezinje ngezi zikhomba kwiipropathi ezinokubakho ze-neuroprotective ze-cannabis, kwaye zibonisa ukuba inokuba yiarhente esebenzayo yokusetyenziswa ekulweni neempawu ZIKANKSZ. nangona uphando luselusana, iziphumo zophando olunjalo zibonisa isithembiso esikhulu sexesha elizayo.

Iziphumo zophando ziqinisekiswe ngu-Israel. Uphononongo luka-2012 Kwiyunivesithi Yaseplymouth, E-UK, lufumanise ukuba i-cannabis yayiphindwe kabini njenge-placebo ekunciphiseni ukuqina kwemisipha kunye neenkantsi ezibangelwa YINKSK. emva kweenyanga ezintathu, abathathi-nxaxheba abasebenzisa i-cannabis babonisa ukunciphisa umlinganiso wokuxhuzula xa kuthelekiswa nabo bathathi-nxaxheba abenzeakunjalo.

Malunga nama-20% ezigulana ezinems ziya kuba neengxaki ezinzulu zokuxinana kwezihlunu. Oku kulingana nokuqina kwemisipha okungalawulekiyo kunye nokuxhuzula, kunye nokulahleka kolawulo lwemisipha okwenzeka xa iiseli zemithambo-luvo ezinoxanduva lokuhamba zonakalisiwe. Lo monakalo ubangelwa kukukrala, kwingqondo nakumqolo ngokukodwa.

Uphononongo luka-2013 olwenziwe Kwiyunivesithi yasetel Aviv lufumanise ukuba I-THC KUNYE NE-CBD inokunceda ukuthintela ukudumba kwezi ndawo zombini. Iziphumo zabo zakhokelela abaphandi ukuba bagqibe kwelokuba i-cannabis, ngelixa ingathi iyeza, inokuqhubela phambili ekunciphiseni ezinye zeempawu ezikhankanywe apha ngasentla.

Uncedo lokugaya

Iingxaki zesisu nazo aziqhelekanga kodwa zixhaphake kakhuluukugula okubangelwa KUKUQHINWA kwamathumbu, iingxaki zokulawula amathumbu nokungakhathalelwa kwamathumbu zonke ezo zinto zinokwenza ubomi bemihla ngemihla bube lusizi. I-Cannabis inokukunceda kule nto. I-70% yamaseli omzimba kwi-intestinal tract. Akumangalisi ukuba i-cannabinoids ibopha kwezi seli zomzimba kwaye inokuzolisa ukudumba emathunjini.

I-THC ikwayinto eyaziwayo yokukhuthaza ukutya, ukukhulula iihomoni kunye nokuqalisa imetabolism. Ngaloo ndlela, i-cannabinoids ayinciphisi kuphela ukuvuvukala kwamathumbu kodwa iphucula ukuveliswa kwejusi yokutya, ekhokelela ekuphuculweni kokutya.

Umzekelo olula, cinga nge-cannabinoids njengokufana namapolisa ezithuthi. Ezi khompawundi zilula zilawula ukuhamba kweehomoni zonxibelelwano ngaphakathi nangaphandle kweeseli amapolisa endlelainto crowdfunding. Xa iqhagamshelwe kwindawo efanelekileyo, I-THC KUNYE NE-CBD zisebenza njengezixhobo zokunceda umzimba usebenze ngokufanelekileyo, uncedisa iinkqubo zokuhamba kwicala elifanelekileyo.

Ngokudibanisa ii-receptors ezithile zeselfowuni, i-cannabinoids inokukwazi:

* Ukunceda ukunciphisa urhudo

* Ukunceda ukuphelisa isicaphucaphu kunye nokuhlanza

* Uncedo lokuphumla izihlunu

* Ukunceda ukunciphisa ukudumba

Uncedo olunokubakho lokulala

Xa imizimba yethu isebenza ngendlela engalawulekiyo — imvakalelo eyaziwa kakuhleabo baneengxaki zempilo yomzimba okanye yengqondo-ukuwa, nokuhlala, ukulala kunokuba ngumceli mngeni onzima kwaye uhlala ungenakoyiswa. Ezinye iintlobo ze-cannabis zinokuba luncedo kakhulu. Iindidi eziphambili ze-Indica zinokuqinisekisa ukuba umzimba kunye nengqondo ziphumle, kungekuphela nje ekuncedeni ukulala ngokukhawuleza, kodwa nokuhlala ulele ixesha elide.

Izigulana ezineentlungu zikwaxela ukulala ngcono emva kokusetyenziswa kwecannabis. Kuphononongo olwenziwe yinkampani YASEBRITANE I-GW Pharmaceuticals, evavanye iziphumo ZE-cbd KUNYE NE-THC kwizigulana ezingama-2,000 ezifumana iintlungu ezingapheliyo, kwafunyaniswa ukuba abathathi-nxaxheba balala ngcono kwaye bafumana iintlungu ezincinci emva kokusetyenziswa kwe-cannabis efanelekileyo.

Ukusetyenziswa KWE-THC ngexesha lokulalaoku kukhokelela ekubeni umsebenzisi achithe ixesha elingakumbi elele. Ngexesha lokulala, umzimba uthatha ixesha lokuzihlaziya. Eli lixesha apho izicubu, amathambo kunye nezihlunu zakhiwe kwakhona. I-immune system iphinda ihlaziye ngeli nqanaba lokulala.

Impilo ye Ocular

Kuqhelekile ukuba izigulana EZINESIFO SEMS zihlaselwe ngumbono omfiliba ngesiquphe, obomvu, okanye iintlungu. Ezinye izigulana zisenokumfameka okwexeshana okanye zibe namehlo angalawulekiyo. Kwakhona, ukuvuvukala ngumbangi. Kwezinye iimeko, I-MS ibangela ukuvuvukala kwe-optic nerve. Oku kuthetha ukuba ukukwazi ukubona kungalahleka ngokuyinxenye okanye ngokupheleleyo de ukukrala kwehle.

I-Cannabis inokunceda ukunciphisa iziphumo eziphazamisayo zems kumbono ngokunciphisa ukudumba kwimithambo-luvo ye-optic. Phezuemva kwexesha, le nkunkuma iyancipha. Ngaphambili, i-Cannabis ibonakaliswe njengonyango olunokubakho kwizifo ezahlukeneyo zamehlo.

Abaphandi bathi izifo eziqhelekileyo ezifana ne-glaucoma kunye ne-retinal degeneration zinokuba yimithambo-luvo kwindalo. Iipropathi ze-neuroprotective ze-cannabis kukholelwa ukuba zinciphisa umonakalo obangelwe lolu hlobo lwesifo.

Iziphumo ze-cannabis zibanzi, kwaye ukusetyenziswa kweekhompawundi ngaphakathi kwe-CANNABIS, njenge-THC, kuye kwaboniswa ngokuphindaphindiweyo ukuba kunempembelelo entle kwiinkqubo emzimbeni ezinceda ukulawula izinto ezinje ngokutya, inkumbulo, amandla okulala, kwaye okona kubaluleke kakhulu, ukusebenza kwenkqubo yomzimba yokuzikhusela. Zonke ezi nkqubo zincinci ziyinxalenye yenkqubo enkulu ye-endocannabinoid.Le misebenzi ebalulekileyo ichaphazeleka kwaye ilawulwa ziikhemikhali kunye neehomoni ezifanayo: i-endocannabinoids.

Njengoko bekutshiwo ngaphambili, i-endocannabinoids yenzeka ngokwendalo emzimbeni, ngelixa i-phytocannabinoids ikhona kwisityalo. Kungakhathaliseki ukuba isifo, i-cannabinoids ezininzi zisebenza ngendlela efanayo esisiseko: zinamathela kwiiseli kwingqondo nasemzimbeni, zitshintsha indlela iiseli ezinxibelelana ngayo. Oko kukuthi, batshintsha indlela iiseli ezinika ngayo imiyalelo ethile.

Ezinye iindlela zamayeza

Olu hlolisiso luye lwabangela ukuba iinkampani zamayeza, EZINJENGEGW Pharma ekhankanywe ngasentla, zisebenzise I-THC kumayeza azo anems. I-Sativex ibisemarikeni Kwi-European Union iminyaka eli-12 kwaye isetyenziselwa ukunyanga imisipha enxulumene NE-MSiintlungu kunye neentlungu.

Ngelixa ichiza libonisiwe kumanqaku amaninzi kwihlabathi liphela, I-Sativex ingaphezulu okanye ngaphantsi isicatshulwa se-cannabis esiphakamileyo esiqulathe ukulingana KWE-THC KUNYE NE-CBD kwi-1: 1 ratio.

I-Sativex ngoku iyafumaneka ngaphandle Kwe-United States kunyango lweempawu ZE-MS kwaye Ngaphakathi Eunited States, ichiza liqhuba uvavanyo lwesigaba sesi-3 ukunyanga iintlungu ezibangelwa ngumhlaza.

Kulabo abangenako ukufikelela Kwi-Sativex, ezi ntlobo ze-cannabis zinokujongwa njengokhetho:

· Enye Ukuya Kwenye (olu hlobo lufana Kakhulu Nesativex)

* Permafrost (phezuluTHC.)

* Ubunzima Obunzima

* Harlequin

* Itsunami Emuncu

Izifundo ezininzi zenziwa kwi-cannabis science-based. Abaphandi kwihlabathi liphela benza izinto ezibalulekileyo ekuqondeni indlela i-cannabis enceda ngayo ukuphatha izifo ezifana NONKSZ.Siyathemba Ukuba isizukulwana esizayo sabaguli siya kuba lula ukufikelela kwesi sityalo sinokutshintsha ubomi kunye neziphumo zaso.