Sativex-isidakamizwa esiyingqayizivele sohlobo lwaso
Yenziwe YI-Gw Pharmaceuticals, inkampani Yasebritane, yayiliyeza lokuqala elisekwe kwi-cannabinoid elenziwe ngesityalo sokwenyani se-cannabis. Ngelixa kukho amayeza afana Ne-Sativex ebijikeleze ixesha elide kunale, into enomdla ngakumbi Malunga Ne-Sativex kukuba yenziwa ngokupheleleyo ngaphandle kwe-lab-synthetic cannabinoids.
Yahluke njani kwi-cannabis buds, tinctures, kunye nezinye iioyile? Ngaba iyafana
i-cannabis yonyango, zombini kunye neyeza? Ngaba kunokwenzeka kwaye kufuneka umguli osebenzisa i-cannabis yonyango asebenzise I-Sativex? Ngaphambi kokudalwa kwayo, ingcamango yokuba i-cannabis ingaba yinxalenye ye "pharma enkulu" ibonakala ingenakwenzeka. Nangona Kunjalo, I-Sativex ibe yinto yebhulohoukudibanisa ihlabathi le-cannabis yezonyango kunye ne-pharma enkulu. Oku kuyenza ibe sisiyobisi esinomdla ngakumbi kwaye inyathelo elibalulekileyo kwindlela eya kwi-cannabis yezonyango Eyurophu.
Sativex-yintoni na?..?
Yadalwa YI-Gw Pharmaceuticals ngo-1998 kwaye yaphawulwa Njenge-sativex®; ngenye indlela eyaziwa ngokuba yi-nabiximols, ngoku iyafumaneka kumazwe angama-30. Yi-cannabis concentrate etyiwa kusetyenziswa isitshizi somlomo kwaye yenziwe kwisityalo sonke se-cannabis, kunye Namayeza E-GW anelayisensi yokuvelisa isixa esikhulu se-cannabis ngeenjongo zonyango. Ukuveliswa kwamachiza kunye namayeza avela kwi-cannabis kubandakanya izinto ezininzi.
Okokuqala, I-Sativex iqulethe i-1:1 ratio YE-CBD KUNYE NE-THC. Ngokuqhelekileyo kunzima ukufumana ukulinganisela okunjaloiimveliso ze-cannabis ezenziwe ziinkampani ezincinci ezingezizo ezamayeza. Kungenxa yokuba I-Sativex ine-cbd kunye NE-THC eyibeka yodwa kwezinye i-cannabinoids zonyango/zamayeza.
Kukho elinye ichiza le-cannabinoid, I-Marinol, ethelekiswa Ne-Sativex; nangona kunjalo, I-Marinol iqulethe kuphela i-cannabinoids eyenziweyo elinganisa indlela YE-CBD kunye NE-CBD. Enyanisweni, i-Sativex mhlawumbi ifana kakhulu nemveliso efana ne-cannabis tinctures, izitshizi zeelwimi kunye neoli ezifumaneka kwi-dispensaries. Ukuba yenziwe yinkampani yezamayeza iyibeka yodwa kwi-cannabis yeentyatyambo kunye nomzi mveliso we-cannabis ekhulayo.
Indlela yokusebenzisa I-Sativex
I-Sativex iza kwifomathi yomlomo yokutshiza eyi-peppermint kwi-flavour. Isitshizi ngasinye sihambisa i-100i-microlitres yolwelo, apho i-2.5 mg yi-CBD, kwaye i-2.7 mg YI-THC. I-oromucosal-ithetha ukuba ifunxwe phantsi kolwimi, kunye nezidlele kunye neentsini-le yeyona ndlela isebenzayo kwaye ikhawulezayo yokuhambisa, njengoko ithintela inkqubo yokugaya. Abasebenzisi be-Sativex baxela ikakhulu iziphumo ebezingalindelekanga ezifanayo njengaye nawuphi na umsebenzisi oqhelekileyo we-cannabis.
Emva kwayo yonke loo nto, i-cannabinoids, enye yazo i-psychoactive kwindalo, ke iziphumo ziyafana ne-cannabis ngokwayo. Abanye abasebenzisi baxela iimvakalelo zeempawu ze-paranoia, ixhala, ukutshintsha kwemood njl.
Ngubani I-Sativex ethengiswayo?
Okubangel ' umdla kukuba, I-Sativex ifumaneka ngomyalelo kumazwe amaninzi apho kungekho mthethweni ukusebenzisa i-cannabis.
Ifransi neaustralia zezona zibalulekileyoumzekelo: isigqebelo kukuba I-Sativex ingamiselwa ngugqirha, kodwa ukusetyenziswa kwe-cannabis yangempela kwiinjongo zonyango kuhlala kungekho mthethweni. Ngako oko kunokutshiwo ukuba, kwiimeko ezininzi, I-Sativex iyeza le-cannabinoid kubantu abangakwazi ukukhula i-cannabis yabo ngezizathu zomthetho. Nangona kunjalo, kwamanye amazwe akulula ukufumana umyalelo We-Sativex, nangona kusemthethweni kumyalelo, njengoko kukho iimeko ezimbalwa kuphela ezithathwa njengonyango. Ukongezelela, kusekho inani elingabalulekanga loogqirha abangavumeli naluphi na uhlobo lonyango nge-cannabinoids.
I-Sativex ihlala imiselwe kubantu abanesifo se-multiple sclerosis, unyango apho esona sizathu siphambili Sativex senziwe. Kunjalongokuqhelekileyo, unyango lwe-spasms ye-muscle enxulumene NE-MS. nangona ingelulo unyango olupheleleyo, njengesixhobo esihle sokulawula iimpawu. Kwamanye amazwe, I-Sativex ikwamiselwe njenge-analgesic yokunceda iintlungu kunye nokuphazamiseka kokulala. Umxholo we-cannabinoid yinto eyenza ukuba isebenze kangaka kunyango lweentlungu, eziseleyo sesinye sezizathu eziqhelekileyo zokusetyenziswa kwe-cannabis yokuzonwabisa.
Kuba I-Sativex yenziwa yinkampani yamayeza, iya isaziwa ngakumbi njengeziyobisi ezisebenzayo. Kungenxa yoko le nto i-GW Pharmaceuticals Kunye Ne-Sativex zibaluleke kakhulu kushishino lwe-cannabis. Oku kuthetha ukuba kukho ubudlelwane obusondeleyo phakathi kwamazwe amabini, okwakucingelwa ukuba ayilungelelananga ngaphambili.
I-Sativex kunye namanye amayeza asekwe kwi-cannabis
I -I-Marinol ekhankanywe ngasentla, enye ifom ye-cannabinoid esekwe kumayeza, iqulethe isithako esisebenzayo se-dronabinol, yinguqulelo eyenziweyo YE-THC. Qaphela ukuba ngelixa I-Sativex ithandwa Kakhulu Eyurophu, ivinjelwe E-USA, ngelixa I-Marinol ivunyiwe yi-Fda.
Nangona iziphumo ezikhawulezileyo Ze-Marinol zinokufana kakhulu nezo Ze-Sativex, kubalulekile ukuba uqaphele ukungafani kwazo. Amayeza avela kwimithombo esekwe kwizityalo ahluke kakhulu kwezo zenziwa ngamachiza. Enye yeendlela eziphambili kunye nezona zibalulekileyo ze-cannabis yinto ebizwa ngokuba yimpembelelo ye-entourage, oko kukuthi ukudityaniswa kwe-terpenes yesityalo, i-flavonoids, i-cannabinoids njl..
Kucacile ukuba, ichiza elenziwe ngezinto ezifana Ne-Marinol alincedi kweli entisiphumo kuba inobudlelwane obude kakhulu kwisityalo sokuqala. I-Marinol yenziwa kuqala ukunyanga isicaphucaphu kunye nokuhlanza okufunyanwa zizigulana ezinomhlaza ezifumana ichemotherapy. Ikwavunyiwe yi-FDA njengonyango lwabantu abanehiv / AIDS, njengoko inokunceda ukuvuselela umdla wokutya kwabo baye bancipha kakhulu.
Elinye ichiza elifana Ne-Sativex Yi-Epidiolex, njengoko, nayo, yenziwe nge-cannabinoids yokwenyani (ngokungafaniyo Ne-Marinol). Nangona kunjalo, ngokungafaniyo Ne-Sativex ayiqulathanga I-THC, kwaye yaqulunqwa ngenjongo yokunyanga ezona ntlobo zimbini zinzima zesifo sokuwa ebantwaneni: I-Dravet syndrome kunye Ne-Lennox-Gastaut syndrome, enganyangekiyo kunyango oluqhelekileyo lweziyobisi kwezinye iindlela zesifo sokuwa. Isithako esisebenzayoKwi-Epidiolex yicannabidiol( CBD) engasebenzi ngengqondo, kwaye yaziwa ngokukwazi kwayo ukunyanga iimpawu zesifo sokuwa.
Ngaphandle KWE-THC, ke akukho siphumo se-psychotropic, kukhuselekile ukusetyenziswa ebantwaneni. Uvavanyo lweklinikhi olwenziwe Nge-Epidiolex lubonise ukuba abantwana abathatha ichiza bafumana ukwehla okukhulu kokuxhuzula kwesifo, sehla malunga ne-40% ngenyanga.
Ekugqibeleni, enye yezinto eziphambili ezinokubeka I-Sativex ngaphandle kwezinye iimveliso ezigxininisayo ezifana neoli engekho imithi, i-tinctures,ukutya njl., ngaba umyinge weziyobisi we-THC KWI-CDC unokubalwa kwaye wenziwe ngokugqibeleleyo, kwaye ke iidosi ngqo zinokulinganiswa ngokulula ngokusetyenziswa ngalunye.
Microdosing LSD
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