Lo mvukeli uthola ukungawuqapheli umsebenzi we-cannabinoids kuphela kwinkqubo yethu, kodwa waveza futhi inqubo yomzimba ethokozisayo enceda umzimba ukugcina ikhaya.
YINTONI IDALA INKQUBO YE-ENDOCANNABINOID?
Ososayensi baye bakwazi ukuchonga izakhi ezintathu eziphambili ezenza inkqubo ye-endocannabinoid: i-endocannabinoids, i-cannabinoid receptors, kunye ne-enzyme.
I-Endocannabinoids ihlanganiswe emzimbeni futhi isebenze njengama-molecule ephawula ngokubopha kuma-ECS receptors. "I-Endo" ithetha "yangaphakathi," kunye ne "cannabinoid" ithetha nayiphi na i-molecule esebenza ezi receptors. Ii-endocannabinoids ezimbini zokuqala emzimbeni ngu-anandamide KUNYE NO-AG.
Inkqubo ye-endocannabinoid iqulethe iindidi ezimbini eziphambili zeerektara:Cb1 ne-CB2. Ezi ndawo zokubopha zivela kwiiseli ezininzi kumzimba wonke. Ama-cannabinoids ahlukahlukene abophe, ukuvimbela, noma ukuguqula umsebenzi walezi zingxenye. Ezi ziquka i-endocannabinoids kunye ne-phytocannabinoids efumaneka kwizityalo kunye ne-cannabinoids eveliswa elebhu. Abaphandi bakholelwa ukuba I-TRPV1 (I-Receptor Transient Type Vanilloid 1) iyinxalenye yenethiwekhi kuba isebenza njengendawo yokubopha I-CBD, I-THC, ne-anandamide.
Ii-enzyme ziiproteins ze-catalyse chemical reactions. Inkqubo ye-endocannabinoid iqulethe i-enzyme yomibini eyakhayo neyophula i-endocannabinoids. I-fatty acid amidohydrolase (FAAH) ingenye ye-enzymes ephambili ekwaziyo ukuphula i-endocannabinoid eyaziwa ngokuthi i-anandamide.
ABISOLIERZANGENRECEPTORS: APHO UKUFUMANA NOKUBA YINTONI NA
Ama-receptors we-Cannabinoid adlala indima ebalulekile ekusebenzeni kwe-endocannabinoid system. Bayasiza ukudlulisa i-endocannabinoid messages ukusuka kwiseli ukuya kwiseli nokusuka ngaphandle ukuya ngaphakathi kweseli. Funda ngakumbi ngendawo kunye neendima zabo ngezantsi.
ZIPHI II-CB1 NE-CB2 RECEPTORS?
Ii-receptors ZE-CB1 zifumaneka kakhulu kwinkqubo yemithambo-luvo esembindini, nangona zikwakhona nakwezinye iindawo ezininzi. Ukuza kuthi ga ngoku, uphando luye lwaqaphela ii-receptors ZE-CB1 kwezi nkalo zilandelayo:
· Ubuchopho
· Intambo yomqolo
· Adipocytes (amafuthaiiseli)
· Isibindi
· Zam zam
· Izihlunu zophahla
· Inkqubo yokutya
· Inkqubo lokuvelisa
Ama-receptors angaphansi kwe-CB2 avela kumanani amancane kakhulu kuwo wonke umzimba. Ezi ndawo zifumaneka ikakhulu kumajoni omzimba, kodwa zibonakala zihleli phantsi kwezinye iindawo ezibalulekileyo zomzimba. Abaphandi bafumana ii-receptors ze-CB2 kwezi ndawo zilandelayo:
· Amajoniiiseli
· Inkqubo yokutya
· Isibindi
* Aphocytes
* Bam bam
· Inkqubo lokuvelisa
KUTHENI SINAZO II-RECEPTORS ZE-CANNABINOID?
Ama-receptors we-Cannabinoid exist kuwo wonke umzimba kumalungu ezinhlobo eziningi zamaseli. Kwelinye icala yindawo extracellular kanti kwelinye umphakathi weseli. inwebu isebenza njengesithinteli sokukhusela.
Uma i-cannabinoid ibopha i-receptor ye-cannabinoid, ithumela uphawu ngaphakathi kweseli elishintsha okwesikhashana umsebenzi weseli.Indawo ye receptor idla ngokubonisa ukuba yeyiphi inkqubo echaphazela.
Ama-receptors e-Cannabinoid asebenza njengabathakathi phakathi kwesikhathi esicutshungulwe kanye nomphakathi weseli. Emva kokusebenza, ama-receptors e-cannabinoid aqale inqubo, ngaleyo ndlela aguqula umsebenzi wamaseli futhi ahamba ndawonye eya ekulingiseni.
YINTONI UMSEBENZI WESIXOKELELWANO SE-ENDOCANNABINOID?
Abaphandi be-Cannabis baye bayiqaphela indalo yokulawula i-homeostatic system ye-endocannabinoid. Oku kuthetha ukuba kuyanceda ukuqinisekisa ukuba ezinye iinkqubo zibaleka kakuhle. Nkqu nee-neuron ziza kubuyisela i-cannabinoids kwi-receptors kwindawo ye-synaptic ukufumanisa ukuba yeyiphi imichiza abafuna ukuyifumana.
Kwakhona ungacinga ngeqondo lobushushu lomzimba njengomzekelo we-homeostasis. Ukuba iwela phantsi kakhulu okanye utsiba phezulu kakhulu,imisebenzi ebonakalayo ayiyi kusebenza ngokufanelekileyo. Imizimba yethu isoloko isebenza ukugcina sikhuselekile kwi 36-37 ° C.
Zonke iinkqubo zomzimba wethu zikhoyo kwimeko yokulingana komzimba kunye ne-endocannabinoids ezinceda ukugcina loo meko. Kwi endocannabinoid
inkqubo idlala indima yokulungiswa kwezi nkqubo zilandelayo:
· Inkqubo yemithambo-luvo esembindini neyeeperipheral
· Inkqubo Endocrine
· Amajoni omzimba
· Metabolism
I-THC IYICHAPHAZELA NJANI INKQUBO YE-ENDOCANNABINOID?
I Phytocannabinoids idla ngokuba nesakhiwo esifanayo se molecularukuba endocannabinoids emizimbeni yethu. I-THC iyafana kakhulu nesakhiwo sayo ku-anandamide, ivumela ukuthi ibophe futhi ivuselele kokubili ama-receptors E-CB1 ne-CB2.
Inkoliso yanamhlanje uxinizelelo lwenkanunu lwale minyaka ilishumi ukuquka I THC njengendidi lokuqala lwecannabinoid. I-THC yinto ye-psychoactive-yenza odumileyo yokuguqula isimo sengqondo ngokubopha kwi-cb1 receptors kwinkqubo ye-nervous central kwaye ikhokelela ekwandeni kwamazinga e-dopamine, phakathi kwezinye iinguqu zomzimba.
Nangona kunjalo, I-THC ne-anandamide ngokukodwa isebenze i-receptor YE-CB1. Oososayensi baphuhlisa iindlela zokwenziwa KWE-THC ezenza isithuba sibe namandla kakhulu, kodwa ngokungafanelekanga. ITHC ibophelele kwi-receptor YE-CB2, apho isebenza njengesinxalenye ye-agonist.
I CBD IHLOBENE KANJANIINKQUBO ENDOCANNABINOID?
Ngokungafaniyo THC, CBD unobudlelwane eliphantsi ezibophelelayo zombini CB1 kunye cb2 receptors. Iziphumo zovavanyo zibonisa ukuba i-CBD ibhloko ze-cb1 receptors phambi kwe-dose ephantsi THC , mhlawumbi inciphisa iziphumo zayo zengqondo.
I-cbd ibophelela kwi-receptor YE-TRPV1, isayithi elininzi okanye ngaphantsi kwenkqubo ye-endocannabinoid. Le receptor yenziwa zii-molecule eziliqela, ngoko ke ezichaphazela iinkqubo ezahlukeneyo zomzimba.
I-cbd ingakhuthaza ngqo i-CB1 ne-cb2 receptors ngokwandisa amazinga e-serum e-anandamide. Oku kungenxa yokuba i-cannabinoid ibonakala ivimbela I-enzyme FAAH, edla ngokwaphula i-anandamide, kwaye ngaloo ndlela I-CBD iyakwazi ukukhusela u-anandamide kwakhona.
INDLELA UKUKHUTHAZA I-ENDOCANNABINOID SYSTEM
Inkqubo ye-endocannabinoid idlalaindima ebalulekileyo ekugcineni ibhalansi yomzimba womntu. Kodwa, kwenzeka ntoni ukuba inkqubo ye-endocannabinoid ayiphumeleli ukusebenza kakuhle? Uphando luye lwafumanisa ukuba wonke umntu une - "endocannabinoid tone" level-igama elichaza ubungakanani be-cannabinoids ejikeleza ngeenxa zonke, kwaye yaveliswa, umzimba womntu.
Ukungabikho kwe-endocannabinoids kungabangela isifo esaziwa ngokuba yi-clinical endocannabinoid deficiency (CD). Ngoko ke, inkqubo yethu ye-endocannabinoid igcinwe njani kwinqanaba layo elifanelekileyo? Ewe, kukho iindlela ezilula nezendalo ukuphazamisa I-ECS yakho:
I-Phytocannabinoids: njengoko kuchaziwe ngasentla, i-cannabinoids efana NE-THC KUNYE NE-CBD inokuchaphazela ii-receptors ze-cannabinoid. Uphando lubonisa ukuba ezi zinto zinganceda ukunciphisa i-endocannabinoid ephantsiumphakamo.
Caryophyllene: Le terpene, ifunyenwe kwimifuno emininzi yasekhitshini (kunye ne-cannabis), isebenza njenge-cannabinoid etyiwayo, kwaye izibophelele ngqo kwi-receptor ye-cb2 yomzimba. Le ndlela yokwenza inceda ikhokelele ekuthuleni kwemithambo-luvo nokuphucuka kwemo yengqondo. I-Rosemary, i-pepper emnyama, amathemba, i-cloves ne-oregano zonke ziqulethe izixa ezinkulu zalo.
I-Omega Fatty Acids: Ingaba ukutya okusemandleni omzimba kunoxanduva lwamanqanaba aphantsi e-endocannabinoid? Mhlawumbi. Umzimba udinga i-omega-3 fatty acid ukuze uhlanganise i-endocannabinoids. Ukutya okuphezulu kwi-omega-3 ziquka iintlanzi, imbewu ye-hemp, i-walnuts, imbewu ye-flax, imbewu ye-chia kunye ne-caviar.
Ukuzivocavoca kwe-Aerobic: Ukubaleka nokuhamba ngebhayisikili kuyindlela elula yokwandisa amazinga e-anandamide engqondweni. Ngaba ukhe waziva uluvo lweeuphoria emva kokuhamba ixesha elide? Amava aziwayonjengoko "ukubaleka okuphezulu" kwakusele kubalwe ziingcali kwi-opioids engapheliyo. Iyajika into yokokuba uandamide angaba yingcambu yezi mvakalelo zihle. Emva kwabo bonke, igama elithi "anandamide" Kwisanskrit ngokwenene lithetha "ulonwabo".
Ezinye I-Cannabinoids Ezityiwayo: I-Cannabis ngokwendalo iveza ngaphezu kwe-100 cannabinoids. Noxa kunjalo, amalungu olu sapho lwamachiza nawo akhutshwa zezinye izityalo.
Nazi ezinye zezinto ezithandwa kakhulu:
· Chili zange: capsaicin (TRPV1)
· Cocoa: N-OleoylEthanolamine Kunye Ne-N-Linoleoyl Ethanolamine (Inqanda I-FAAH)
· Truffles: anandamide(10 MEYI 2015 NGOKUBHALA)
· Echinacea: alkamidok (cb2)
· Ke: umakarid (CB1)
· Kuba: yangonin (CB1)
· Pepperine omnyama: umbhobho (TRPV1)
· Gingerol: gingerol kunye nezingerone (TRPV1)
ECS: INKQUBO EBALULEKILEYO KUMZIMBA
Indlela i-endocannabinoid eboniswe ngayo ibaluleke kakhulu kumzimba womntu. Yinkqubo enoxanduva lokulawula iinkqubo ezininzi emzimbeni, ngoko ke kubalulekile ukuqinisekisa UKUBA I-ECS yomzimba ikhathalelwe kakuhle. Iindlela zokwenza uphando olungakumbiiyancomeka, njengoko isakhono sayo esipheleleyo siyaqhubeka ukuba sisihloko esithandekayo sokufunda ngenzululwazi eqhubekayo.
Iimbono ezixhaphakileyo malunga Iintlobo Autoflowing Ezihambelayo Ze Cannabis
Imbewu okanye ukusika: kukuphi okungcono ukukhula kwe-cannabis?
