UHofmann kamva waba nelungelo elilodwa lomenzi wechiza i-4-AcO-DMT, eyalityalwa emva koko, de yaphinda yavela njengechiza lepati ngeminyaka yoo-1990. Kwi-1999, unjingalwazi kunye nososayensi we-psychedelic uDavid E. Nichols uzame ukubuyisela umdla kwi-4-AcO-DMT ngokuyibonisa njengenye indlela ekhuselekileyo neyindleko kwi-psilocybin, njengoko kulula kakhulu kwaye ingabizi kakhulu ukuyidibanisa. Kwiminyaka eyi-20 kamva kwaye akukho mntu wenze uphando olulodwa olubalulekileyo malunga nokhuseleko kunye neenzuzo ezinokuthi zenzeke kwi-4-AcO-DMT, nangona ukuthandwa kwayo okukhulayo phakathi kwabasebenzisi be-psychedelics.
I-4-AcO-DMT iza ngendlela yomgubo onokuginywa okanye ukurhorhozela. Njengazo zonke ii-psychedelics, i-micro-doses ingundoqo ekunqumeni imiphumo kunye namava, ngokutsho kweengxelo, zifana kakhulu namakhowa okanye i-DMT.
