Izifundo zokuqala, ezingalawulwayo zibonisa ukuba xa zithathwa kwindawo ekhuselekileyo, i-5MeO-DMT ihambelana nokuphuculwa kweempawu zokudakumba, ukuxhalaba, i-PTSD, kunye nokusetyenziswa kakubi kweziyobisi. Ngaphandle kwale nzuzo enokubakho, amava abukhali okusebenzisa i-psychedelics anokuba ngumngeni kwaye abandakanye uloyiko olongezelelekileyo, i-paranoia, ukudakumba, ukuhlukaniswa, kunye nokunye.
Uphononongo oluhlaziyiweyo olupapashwe kwiJenali ye-Psychedelic Studies, isampula yabasebenzisi be-5MeO-DMT kuphando lwe-Intanethi. Isampuli yahlulahlulwe ngamaqela e-2 - abasebenzisi kwisimo esicwangcisiweyo (imikhosi) kunye nokuhlolwa kwangaphambili, ukulungiswa kwengqondo kunye nesikhokelo, ngokuchasene nabasebenzisi kwisimo esingamiselwanga, ekhaya okanye kumthendeleko. Zonke izifundo zazalisa umva iphepha lemibuzo ukuhlola amava azo antsonkothileyo nokuvavanya ubungakanani bemingeni yamava azo.
Iziphumo zophononongo zibonisa ukuba ukusetyenziswa kwe-5MeO-DMT kuvelise amava angaqondakaliyo kumaqela omabini, kwaye amava axelwe njengokomoya kwaye alungile ngakumbi ngabaphenduli beqela elimiselweyo. Kwa eli qela linye liphinde lachaza amava abaluleke ngakumbi angaqondakaliyo (83% vs. 54%).