Iifama ze-colonial zaseYurophu zasebenzisa njenge-psychotropic ngendlela ye-tinctures (efakwe kwi-alcohol okanye iviniga). Ukuza kuthi ga kutsha nje, esi sityalo besisaziwa kakhulu ngaphandle koMzantsi Afrika. Nangona kunjalo, iqala ukufumana ingqalelo kwiinzuzo ezinokuzinikezela (njengokukhuthaza ukuphumla kunye nokuphucula isimo sengqondo).
Isicatshulwa se-Sceletium tortuosum sinokusebenza njenge-antidepressant yendalo. Kwizifundo zeklinikhi, abantu abathathe iSceletium tortuosum (efana neZambrin, eyona sicatshulwa sixhaphakileyo kwimarike) baxele ubuthongo obuphucukileyo kunye nokuncipha koxinzelelo.
Abanye oogqirha bengqondo eMzantsi Afrika bamisela isicatshulwa se-Kanna kwizigulana ezinoxinzelelo, ukudakumba okungephi (dysthymia) kunye nexhala. Kwezinye iimeko, izigulana ziphendule ngcono kwi-Kanna kune-antidepressants eziqhelekileyo ezifana ne-citalopram.
Ngokwamayeza esintu kunye nezifundo zezilwanyana, isicatshulwa se-canna sisisombululo esisebenzayo sentlungu yendalo. Amagcisa ayedla ngokuyihlikihla iKanna kwimilenze ebuhlungu yabazingeli neyabalimi, yaye abafazi abakhulelweyo babeyihlafuna ukuze bathomalalise iintlungu zabo. Bade banike iintsana ezikhalayo ngamathontsi eKanna ukuze zikwazi ukulala.
Iidosi eziphezulu ze-Kanna zivula ii-opioid receptors kwingqondo, ngoko ke isebenza njenge-painkiller esebenzayo. Nangona kunjalo, ngokungafaniyo nezithomalalisi zentlungu ezichazwe ngugqirha, uKanna akabonakali ngathi uyakhobokisa. Iikhompawundi ezisebenzayo ze-Kanna nazo zibophelela kunye ne-cholecystokinin receptors, ukunciphisa indlala, enokunceda ukunciphisa ukutya kunye nokulwa nokukhuluphala.
