I-MDMA yaqalwa ngo-1912 nguMerck. Yathi kamva yasetyenziswa ukomeleza unyango lwengqondo ngeminyaka yoo-1970 xa yathi yaduma kakhulu, yaza kamva yajika yaba lichiza lasesitratweni ngeminyaka yee-1980s’ imijuxuzo kunye nemidyarho.
Okwangoku, i-MDMA ayinazo iimpawu zonyango ezamkelwe ngokusemthethweni. Phambi kokuba ivalwe ngokubanzi, ibisetyenziswa kunyango lwengqondo ikakhulu ngeminyaka yoo-1970 kulandela ukuthethelelwa kukaTimothy Leary malunga neziyobisi zengqondo, eyathi yafumana amandla ngentshukumo ye-counterculture. Ngo-2017, i-United States FDA yavuma uphando olulinganiselweyo malunga ne-MDMA-enhanced psychotherapy kubantu abaphethwe yi-post-traumatic stress disorder (PTSD), ekhuthazwa bubungqina bokuqala beziphumo ezilungileyo.
I-MDMA iphucula umsebenzi weekhemikhali ezintathu zobuchopho - iDopamine, evelisa amandla okwandisiweyo; I-Norepinephrine, eyandisa izinga lentliziyo kunye noxinzelelo lwegazi; kunye neSerotonin, echaphazela isimo sengqondo, ukuthanda ukutya, ukulala, kunye nokuvusa inkanuko yesini. Ukunyuka kwamanqanaba e-serotonin kusenokwenzeka ukuba ngunobangela wokusondelelana ngokweemvakalelo, umoya ophakamileyo kunye novelwano olufunyanwa phantsi kwempembelelo ye-MDMA.
