Ucaryophyllene wafunyaniswa kuphononongo lwesilwanyana enye ukunciphisa iintlungu zokukrala nemithambo-luvo, kwaye abaphandi bacebisa ukuba kube luncedo ekunyangeni iintlungu zexesha elide. Oku kungenzeka ngenxa yesakhiwo esahlukileyo se-terpene esivumela ukubopha lula kwi-receptors YE-CB2. I-cb2 receptors ifumaneka kwinkqubo ye-endocannabinoid yeperipheral, kunokuba ingqondo, ethetha ukuba inokunceda ukunciphisa ukuvuvukala ngaphandle kokwenza umsebenzisi ophezulu.
I-terpene nayo idla ngokufumaneka kumalaphu, i-pepper emnyama nesinamon, kwaye ngezinye iindlela eziphezulu ezivela kwi-cannabis ngamazinga aphakamileyo E-Caryophyllene angatsho ukulinganisa oku, nabasebenzisi bathi inika iimvakalelo eshushu kunye ne-spice. Iiterpenes nazo zinoxanduva lweendawo ezifikelelayo zezityalo kwaye oko kukuthikutheni I-Caryophyllene e-dominant cannabis enamandla kuthiwe ibe nevumba elifana nesinamon kunye namavukuthu.